职员
  • 学术带头人
  • 功能影像
  • 分子影像
  • 程然 医学影像学院

    机构 : 天津医科大学

    部门 : 医学影像学院

    邮箱 : rancheng@tmu.edu.cn

    地址 : 天津市河西区广东路1号


    个人简介:

    天津医科大学医学影像学院讲师。2011 年6 月毕业于河北大学药学院,被授予理学学士学位。同年进入天津大学药学院赵康/杜云飞课题组开始博士研究。2015 年8 月至2017 年3 月,在美国哈佛医学院/麻省总医院Steven H. Liang课题组公派联合培养。2018 年1 月毕业于天津大学,被授予工学博士学位。2018 年 1月进入天津医科大学医学影像学院参加工作。研究工作涉及合成化学与分子影像学等领域。共发表SCI论文12篇,其中以第一作者/共同第一作者身份发表文章5篇,单篇最高影响因子11.994。现主持国家自然科学基金青年科学基金项目1项。


    教育经历:

    1. 2015/08–2017/03,美国哈佛医学院/麻省总医院,核医学与分子影像科,国家公派联合培养博士生,导师:Steven H. Liang;

    2. 2011/09–2018/01,天津大学,药学院,博士,导师:赵康/杜云飞;

    3. 2007/09–2011/06,河北大学,药学院,本科。


    科研与学术工作经历:


    1. 2018/01–至今,天津医科大学,医学影像学院,讲师。

    主持或参加科研项目及人才计划项目情况:

    1. 国家自然科学基金青年科学基金项目,81801770,氟-18标记的4-哌啶基氮杂环丁烷二酰胺类可逆型单酰基甘油酯酶正电子示踪剂研究,2019/01至2021/12,21万元,在研,主持。

    2. 国家自然科学基金面上项目,21472136,高价碘试剂介导下通过串联反应构建杂环化合物的新方法研究,2015/01-2018/12,80万元,已结题,参与。

    3. 国家自然科学基金专项基金项目,21342001,降冰片烯介导的过渡金属催化的碳氢活化环合串联反应新型方法学研究和在天然产物骨架构建中的应用,2013/01-2013/12,10万元,已结题,参与。


    代表性研究成果:

    (1) Ran Cheng#, Wakana Mori#, Longle Ma, Mireille Alhouayek, Akiko Hatori, Yiding Zhang, Daisuke Ogasawara, Gengyang Yuan, Zhen Chen, Xiaofei Zhang, Hang Shi, Tomoteru Yamasaki, Lin Xie, Katsushi Kumata, Masayuki Fujinaga, Yuji Nagai, Takafumi Minamimoto, Mona Svensson, Lu Wang, Yunfei Du, Mary Jo Ondrechen, Neil Vasdev, Benjamin F. Cravatt, Christopher Fowler, Ming-Rong Zhang*, Steven H. Liang*. In Vitro and in Vivo Evaluation of 11C-Labeled Azetidinecarboxylates for Imaging Monoacylglycerol Lipase by PET Imaging Studies. Journal of Medicinal Chemistry, 2018, 61(6), 2278-2291.

    (2) Zhongxiang Yun, Ran Cheng, Jiyun Sun, Daisy Zhang-Negrerie, Yunfei Du*. Iodobenzene Dichloride/Zinc Chloride-Mediated Synthesis of N-Alkoxyindole-3-carbonitriles from 3-Alkoxyimino-2-arylalkylnitriles via Intramolecular Heterocyclization. Advanced Synthesis & Catalysis, 2018, 360(2), 250-254.

    (3) Kenneth Dahl, Thomas L. Collier, Ran Cheng, Xiaofei Zhang, Oleg Sadovski, Steven H. Liang*; Neil Vasdev*. “In‐loop” [11C]CO2 fixation: Prototype and proof of concept, Journal of  Labelled Compounds and Radiopharmaceuticals 2018, 61(3), 252-262.

    (4) Lu Wang#, Ran Cheng#, Masayuki Fujinaga, Jian Yang, Yiding Zhang, Akiko Hatori, Katsushi Kumata, Jing Yang, Neil Vasdev, Yunfei Du, Chongzhao Ran, Ming-Rong Zhang*, Steven H. Liang*. Journal of Medicinal Chemistry, 2017, 60(12), 5222-5227.

    (5) Xiaofei Zhang#, Katsushi Kumata#, Tomoteru Yamasaki, Ran Cheng, Akiko Hatori, Longle Ma, Yiding Zhang, Lin Xie, Lu Wang, Hye Jin Kang, Douglas J. Sheffler, Nicholas D. P. Cosford, Ming-Rong Zhang*, Steven H. Liang*. Synthesis and Preliminary Studies of a Novel Negative Allosteric Modulator, 7-((2,5-Dioxopyrrolidin-1-yl)methyl)-4-(2-fluoro-4- [11C]methoxyphen-yl) quinoline-2-carboxamide for Imaging of Metabotropic Glutamate Receptor 2. ACS Chemical Neuroscience 2017, 8(9), 1937-1948.

    (6) Jian Zheng#, Ran Cheng#, Jin-Hong Lin, Dong-Hai Yu, Longle Ma, Lina Jia, Lan Zhang, Lu Wang, Ji-Chang Xiao*, Steven H. Liang*. An Unconventional Mechanistic Insight into SCF3 Formation from Difluorocarbene: Preparation of 18F-Labeled a-SCF3 Carbonyl Compounds. Angewandte Chemie International Edition 2017, 56(12), 3196-3200.

    (7) Zheliang Yuan#, Ran Cheng#, Pinhong Chen, Guosheng Liu*, Steven H. Liang*. Efficient Pathway for the Preparation of Aryl(isoquinoline)-iodonium-(III) Salts and Synthesis of Radiofluorinated Isoquinolines. Angewandte Chemie International Edition 2016, 55(39), 11882-11886.

    (8) Lu Wang#, Wakana Mori#, Ran Cheng, Joji Yui, Akiko Hatori, Longle Ma, Yiding Zhang, Benjamin H. Rotstein, Masayuki Fujinaga, Yoko Shimoda, Tomoteru Yamasaki, Lin Xie, Yuji Nagai, Takafumi Minamimoto, Makoto Higuchi, Neil Vasdev, Ming-Rong Zhang*, Steven H. Liang*. Synthesis and Preclinical Evaluation of Sulfonamido-based [11C-Carbonyl]-Carbamates and Ureas for Imaging Monoacylglycerol Lipase. Theranostics 2016, 6(8), 1145-1159.

    (9) Ningning Zhang, Ran Cheng, Daisy Zhang-Negrerie, Yunfei Du*, Kang Zhao*. Hypervalent Iodine-Mediated Oxygenation of N,NDiaryl Tertiary Amines: Intramolecular Functionalization of sp3 C−H Bonds Adjacent to Nitrogen. The Journal of Organic Chemistry 2014, 79(21), 10581-10587.

    (10) Ran Cheng, Linlin Tang, Tianjian Guo, Daisy Zhang-Negrerie, Yunfei Du, * Kang Zhao. * Oxidant- and metal-free synthesis of 4(3H)-quinazolinones from 2-amino-N-methoxybenzamidesand aldehydes via acidpromoted cyclocondensation and elimination. RSC Advances. 2014, 4(50), 26434-26438.

    (11) Ran, Cheng, Tianjian Guo, Daisy Zhang-Negrerie, Yunfei Du*, Kang Zhao*. One-Pot Synthesis of Quinazolinones from Anthranilamides and Aldehydes via p-Toluenesulfonic Acid Catalyzed Cyclocondensation and Phenyliodine Diacetate Mediated Oxidative Dehydrogenation. Synthesis. 2013, 45(21), 2998-3006.

    (12) Xin Liu, Ran Cheng, Feifei Zhao, Daisy Zhang-Negrerie, Yunfei Du*, Kang Zhao*. Direct βAcyloxylation of Enamines via PhIO-Mediated Intermolecular Oxidative C-O Bond Formation and Its Application to the Synthesis of Oxazoles. Organic Letters, 2012, 14(21), 5480-5483.