学术带头人
  • 学术带头人
  • 功能影像
  • 分子影像
  • 学术带头人
    于春水 主任医师/教授
    • 个人简介

      于春水,男,48岁,主任医师/教授,天津医科大学副校长,天津医科大学医学影像学院院长,天津医科大学总医院医学影像科主任。人事部“新世纪百千万人才工程”人选,国务院政府特殊津贴专家,“国家杰出青年科学基金”获得者,天津市高等学校教学名师。目前现任中华医学会放射学分会常务委员,中国装备协会磁共振专业委员会常委,天津市医学会放射学分会第八届委员会主任委员。所带领科研团队入选天津市“131”创新型人才团队、天津市高等学校教学创新团队。累计培养博士研究生24名(毕业13名),硕士研究生46名(毕业32名),研究生以第一作者发表SCI论文55篇,其中25篇影响因子在5以上, 1人获得天津市优秀博士论文、4人获得天津市优秀硕士论文。长期从事基于磁共振成像的人脑网络连接研究,牵头组织了国内规模最大的影像遗传学多中心研究项目。在该领域累计发表 SCI 收录论文 94 篇(JCR 一区论文 69 篇;累计 SCI 他引 1745 次;H 指数 25,其中 63 篇为第一或通讯作者)。 2009 年至今,累计发表 SCI 收录论文 84 篇(JCR 一区论文 63 篇;领域排名前 10%杂志的论文 41 篇;累计 SCI 他引 623 次),其中第一或通讯作者 61 篇(JCR 一区论文 38 篇;领域排名前 10%杂志的论文 24 篇,7篇发表在领域排名第一的杂志)。主持国家重点研发计划,杰出青年基金等国家和省部级课题11项,其中国家级6项。作为主要完成人获得省部级科技奖励9 项,其中一等奖2项(排名第二和第四)。

    • 教育经历

      1999/09-2002/06,天津医科大学,影像医学与核医学,博士研究生,导师廉宗澄

      1995/09-1998/06,天津医科大学,人体解剖学,硕士研究生,

      1989/09-1994/06,天津医科大学,临床医学,本科/学士

    • 科研与学术工作经历

      2017/1-至今:天津医科大学,副校长

      2011/1-至今:天津医科大学医学影像学院,院长

      2011/1-至今: 天津医科大学总医院,科主任

      2009/06-至今:天津医科大学总医院,教授、主任医师

      2008/12- 2009/05:首都医科大学宣武医院,主任医师

      2004/07- 2008/11:首都医科大学宣武医院,副主任医师

      2002/07- 2004/06:首都医科大学宣武医院,博士后

      1994/07-1999/08:天津医科大学,助教

    • 主持或参加科研项目(课题)及人才计划项目情况

      1. 国家重点研发计划重大慢性非传染性疾病防控研究,精神分裂症早期个体化诊疗生物学标记体系研究,起止时间2018/09-2020/12,总经费978万元,项目负责人,在研

      2. 天津市科技计划项目,基于多模态MRI技术的精神分裂症亚型精准诊断和疗效预测研究,起止时间2017/10-2020/09,总经费200万元,项目负责人,在研

      3. 国家自然科学基金杰出青年基金项目,磁共振脑功能成像,起止时间2015/1-2019/12,总经费400万元,项目负责人,在研

    • 代表性研究成果

      一、期刊论文

      1. 第一作者论文

      (1)Liu, Y. #, Yu, C. # , Zhang, X., Liu, J., Duan, Y., Alexander-Bloch AF., Liu, B., Jiang, T. , Bullmore E. , Impaired Long Distance Functional Connectivity and Weighted Network Architecture in Alzheimer's Disease, Cereb Cortex, 2014, 24(6): 1422-1435.

      (2)Yu, C., Liu, Y., Li, J., Zhou, Y., Wang, K., Tian, L., Qin, W., Jiang, T., Li, K. , Altered functional connectivity of primary visual cortex in early blindness, Hum Brain Mapp, 2010, 29(5): 533-543.

      (3)Liu, B. #, Li, J. # , Yu, C. # , Li, Y., Liu, Y., Song, M., Fan, M., Li, K., Jiang, T. , Haplotypes of catechol-O-methyltransferase modulate intelligence-related brain white matter integrity, Neuroimage, 2010, 50(1): 243-249.

      (4)Wang, L. #, Yu, C. #, Chen, H., Qin, W., He, Y., Fan, F., Zhang, Y., Wang, M., Li, K., Zang, Y., Woodward T, Zhu, C. , Dynamic functional reorganization of the motor execution network after stroke. Brain, 2010, 133(4): 1224-1238.

      (5)Yu, C ., Li ,J. , Liu ,Y ., Qin, W., Li, Y., Shu, N., Jiang, T., Li, K. , White matter tract integrity and intelligence in patients with mental retardation and healthy adults, Neuroimage, 2008, 40(4): 1533-1541.

      (6)Yu, C., Lin, F., Jiang, T., Qin, W., Sun, H., Chan, P., Li, K. , Pathogenesis of Normal-appearing White Matter Damage in Neuromyelitis Optica: Diffusion-Tensor MR Imaging1, Radiology, 2008, 246(1):222-8.

      (7)Yu, C., Zhu, C Z., Xuan, Y., Qin, W., Sun, H., Chan, P., Li, K C., Relapsing neuromyelitis optica and relapsing-remitting multiple sclerosis: differentiation at diffusion-tensor MR imaging of corpus callosum, Radiology, 2007, 244(1): 249-56.

      (8)Yu, C., Shu, N., Li, J., Qin, W., Jiang, T., Li, K. , Plasticity of the corticospinal tract in early blindness revealed by quantitative analysis of fractional anisotropy based on diffusion tensor tractography, Neuroimage, 2007, 36(2): 411-417.

      (9)Liu, Y. #, Yu, C. # , Liang, M., Li, J., Tian, L., Zhou, Y., Qin, W., Li, K., Jiang, T. , Whole brain functional connectivity in the early blind, Brain, 2007,130(8): 2085-2096.

      (10)Lin, F. # , Yu, C. # , Li, K., Li, X., Qin, W., Sun, H., Chan, P., Jiang, T. , Quantitative analysis along the pyramidal tract by length-normalized parameterization based on diffusion tensor tractography: Application to patients with relapsing neuromyelitis optica, Neuroimage, 2006,33(1): 154-160.


      (11)Lin, F. # , Yu, C. #, Li, K., Zhu, C., Zhu, W., Qin, W., Duan, Y., Xuan, Y., Sun, H., Chan, P., Jiang, T. ,  Discriminative analysis of relapsing neuromyelitis optica and relapsing-remitting multiple sclerosis based on two-dimensional histogram from diffusion tensor imaging, Neuroimage, 2006, 31(2): 543-549.


      2.通讯作者论文

      (1)Guo, X., Zhu, J., Zhang, N., Zhang, L., Qi, Y., Cai, H., Zhang, X., Sun, J., Wang, Q., Yang, L., Shi, F.D.,Yu, C.*, Altered neurovascular coupling in neuromyelitis optica, Hum Brain Mapp, 2018.

      (2)Xu, Q., Fu, J., Liu, F., Qin, W., Liu, B., Jiang, T.,Yu, C.*, Left Parietal Functional Connectivity Mediates the Association Between COMT rs4633 and Verbal Intelligence in Healthy Adults, Front Neurosci, 2018, 12: 233.

      (3)Wang, C., Liu, B., Zhang, X., Cui, Y., Yu, C.*,Jiang, T.*, Multilocus genetic profile in dopaminergic pathway modulates the striatum and working memory, Sci Rep, 2018, 8(1): 5372.

      (4)Zhang, X., Guo, X., Zhang, N., Cai, H., Sun, J., Wang, Q., Qi, Y., Zhang, L., Yang, L., Shi, F.D.,Yu, C.*, Cerebral Blood Flow Changes in Multiple Sclerosis and Neuromyelitis Optica and Their Correlations With Clinical Disability, Front Neurol, 2018, 9: 305.

      (5)Sun, C.Y., Cao, Z., Zhang, X.J., Sun, R., Yu, C.*,Yang, X.*, Cascade-amplifying synergistic effects of chemo-photodynamic therapy using ROS-responsive polymeric nanocarriers, Theranostics, 2018, 8(11): 2939-2953.

      (6)Liu, J., Wang, C., Diao, Q., Qin, W., Cheng, J.,Yu, C.*, Connection Disruption Underlying Attention Deficit in Subcortical Stroke, Radiology, 2018, 288(1): 186-194.

      (7)Xu, Q., Xiong, Y., Yuan, C., Liu, F., Zhao, F., Shen, J., Qin, W.,Yu, C.*, ZNF804A rs1344706 interacts with COMT rs4680 to affect prefrontal volume in healthy adults, Brain Imaging Behav, 2017.

      (8)Zhu J, Zhuo C, Xu L, Liu F, Qin W, Yu, C*. Altered Coupling Between Resting-State Cerebral Blood Flow and Functional Connectivity in Schizophrenia, Schizophr Bull, 2017, 43(6).

      (9)Jiang L, Liu J, Wang C, Guo J, Cheng J, Han T, Miao P, Cao C, Yu, C*. Structural Alterations in Chronic Capsular versus Pontine Stroke, Radiology, 2017, 285(1):214-222.

      (10)Zhuo C, Zhu J, Qin W, Qu H, Ma X, Yu, C*. Cerebral blood flow alterations specific to auditory verbal hallucinations in schizophrenia, Br J Psychiatry, 2017, 210(3):209-215.

      (11)Xu Y, Qin W, Zhuo C, Xu L, Zhu J, Liu X, Yu, C*. Selective functional disconnection of the orbitofrontal subregions in schizophrenia, Psychol Med, 2017, 47(9):1637-1646.

      (12)Xu J, Qin W, Li Q, Li W, Liu F, Liu B, Jiang T, Yu, C*. Prefrontal Volume Mediates Effect of COMT Polymorphism on Interference Resolution Capacity in Healthy Male Adults, Cereb Cortex. 2016, cercor;bhw301v1.

      (13)Zhang N, Liu H, Qin W, Liu B, Jiang T, Yu, C*. APOE and KIBRA Interactions on Brain Functional Connectivity in Healthy Young Adults, Cereb Cortex. 2016.

      (14)Wang J, Qin W, Liu F, Liu B, Zhou Y, Jiang T, Yu, C*. Sex-specific mediation effect of the right fusiform face area volume on the association between variants in repeat length of AVPR1A RS3 and altruistic behavior in healthy adults, Hum Brain Mapp, 2016, 37:2700-9.

      (15) Li W, Liu B, Xu J, Jiang T, Yu, C*. Interaction of COMT rs4680 and BDNF rs6265 polymorphisms on functional connectivity density of the left frontal eye field in healthy young adults, Hum Brain Mapp, 2016, 37:2468-78.

      (16)Ding H, Qin W, Liang M, Ming D, Wan B, Li Q, Yu, C*. Cross-modal activation of auditory regions during visuo-spatial working memory in early deafness, Brain, 2015, 138(Pt 9):2750-65.

      (17)Qin W, Xuan Y, Liu Y, Jiang T, Yu, C*. Functional Connectivity Density in Congenitally and Late Blind Subjects, Cereb Cortex, 2015, 25(9):2507-16.

      (18)Liu J, Qin W, Zhang J, Zhang X*, Yu, C*. Enhanced interhemispheric functional connectivity compensates for anatomical connection damages in subcortical stroke, Stroke, 2015, 46(4):1045-51.

      (19)Wang D, Zhou Y, Zhuo C, Qin W, Zhu J, Liu H, Xu L, Yu, C*. Altered functional connectivity of the cingulate subregions in schizophrenia, Transl Psychiatry, 2015, 5(6):e575.

      (20)Liu H, Qin W, Qi H, Jiang T, Yu, C*. Parcellation of the human orbitofrontal cortex based on gray matter volume covariance, Hum Brain Mapp, 2015, 36(2):538-48.

      (21)Zhang, P., Qin, W., Wang, D., Liu B., Zhang Y., Jiang T., Yu C. *, Impacts of PICALM and CLU variants associated with Alzheimer’s disease on the functional connectivity of the hippocampus in healthy young adults, Brain Structure & Function, 2015, 220(3): 1463-1475.

      (22)Qin, W., Xuan, Y., Liu, Y., Jiang, T., Yu, C. *, Functional Connectivity Density in Congenitally and Late Blind Subjects, Cereb Cortex, 2015, 25(9).

      (23)Liu, B., Fan, L., Cui, Y., Zhang, X., Hou, B., Li, Y., Qin, W., Wang, D., Yu, C. *, Jiang, T. *, DISC1 Ser704Cys impacts thalamic-prefrontal connectivity, Brain Structure & Function, 2015, 220(1): 91-100.

      (24)Zhang, J., Meng, L., Qin, W., Liu, N., Shi, FD., Yu, C. *, Structural Damage and Functional Reorganization in Ipsilesional M1 in Well-Recovered Patients With Subcortical Stroke, Stroke, 2014, 45(3): 788-793.

      (25)Wang, C., Qin, W., Zhang, J., Tian, T., Li, Y., Meng, L., Zhang, X., Yu, C. *, Altered functional organization within and between resting-state networks in chronic subcortical infarction, Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014, 34(4): 597-605.

      (26)He, X., Qin, W., Liu, Y., Zhang, X., Duan, Y., Song, J., Li, K., Jiang, T., Yu, C. *, Abnormal salience network in normal aging and in amnestic mild cognitive impairment and Alzheimer's disease, Hum Brain Mapp, 2014, 35(7): 3446-3464.

      (27)Wang, J., Qin, W., Liu, B., Zhou, Y., Wang, D., Zhang, Y., Jiang, T.*, Yu, C. *, Neural mechanisms of oxytocin receptor gene mediating anxiety-related temperament, Brain Structure & Function, 2014, 219(5): 1543-1554.

      (28)Wang, D., Qin, W., Liu, Y., Zhang, Y., Jiang, T.*, Yu, C. *, Altered Resting-State Network Connectivity in Congenital Blind, Hum Brain Mapp, 2014, 35(6): 2573-2581.

      (29)Tian, T., Qin, W., Liu, B., Jiang, T., Yu, C. *, Functional connectivity in healthy subjects is nonlinearly modulated by the COMT and DRD2 polymorphisms in a functional system-dependent manner, J Neurosci, 2013, 33(44): 17519-17526.

      (30)Fan, F., Zhu, C., Chen, H., Qin, W., Ji, X., Wang, L., Zhang, Y., Zhu, L., Yu, C. *, Dynamic brain structural changes after left hemisphere subcortical stroke, Hum Brain Mapp, 2013, 34(8): 1872-1881.

      (31)Wang, J., Qin, W., Liu, B., Wang, D., Zhang, Y., Jiang, T. *, Yu, C. *, Variant in OXTR gene and functional connectivity of the hypothalamus in normal subjects, NeuroImage, 2013, 81: 199-204.

      (32)Li, W., Qin, W., Liu, H., Fan, L., Wang, J., Jiang, T. *, Yu, C. *, Subregions of the human superior frontal gyrus and their connections, NeuroImage, 2013, 78: 46-58.

      (33)Wang, D., Liu, B., Qin, W., Wang, J., Zhang, Y., Jiang, T. *, Yu, C. *, KIBRA gene variants are associated with synchronization within the default-mode and executive control networks, NeuroImage, 2013, 69: 213-222.

      (34)Liu, H., Qin, W., Li, W., Fan, L., Wang, J., Jiang, T. *, Yu, C. *, Connectivity-Based Parcellation of the Human Frontal Pole with Diffusion Tensor Imaging, J Neurosci, 2013, 33(16): 6782-6790.

      (35)Zhang, Q., Wang, D., Qin, W., Li, Q., Chen, B., Zhang, Y. *, Yu, C. *, Altered Resting-State Brain Activity in Obstructive Sleep Apnea Running title: Resting-State Brain activity in OSA, Sleep, 2013, 36(5): 651-659.

      (36)Li, J., Liu, Y., Qin, W., Jiang, J., Qiu, Z., Xu, J., Yu, C. *, Jiang, T. *, Age of Onset of Blindness Affects Brain Anatomical Networks Constructed Using Diffusion Tensor Tractography, Cereb Cortex, 2012, 23(3): 542-551.

      (37)Wang, J., Fan, L., Zhang, Y., Liu, Y., Jiang, D., Zhang, Y., Yu, C. *, Jiang, T. *, Tractography‐based parcellation of the human left inferior parietal lobule, NeuroImage, 2012, 63(2): 641-652.

      (38)Sang, L., Qin, W., Liu, Y., Han, W., Zhang, Y., Jiang, T. *, Yu, C. *, Resting-state functional connectivity of the vermal and hemispheric subregions of the cerebellum with both the cerebral cortical networks and subcortical structures, NeuroImage, 2012, 61(4): 1213-1225.

      (39)Yu, C. *, Zhou, Y., Liu, Y., Jiang, T., Dong, H., Zhang, Y., Walter M, Functional segregation of the human cingulate cortex is confirmed by functional connectivity based neuroanatomical parcellation, Neuroimage, 2011, 54(4): 2571-2581.

      (40)Liu, B., Song, M., Li, J., Liu, Y., Li, K., Yu, C. *, Jiang, T. *, Prefrontal-related functional connectivities within the default network are modulated by COMT val158met in healthy young adults, J Neurosci, 2010, 30(1): 64-69.

      (41)Shu, N., Li, J., Li, K., Yu, C. *, Jiang, T. *, Abnormal diffusion of cerebral white matter in early blindness, Hum Brain Mapp, 2009, 30(1): 220-227.

      (42)Jiang, J., Zhu, W., Shi, F., Liu, Y., Li, J., Qin, W., Li, K., Yu, C. *, Jiang, T. *, Thick Visual Cortex in the Early Blind, J Neurosci, 2009,29(7): 2205-2211

      (43)Yu, C. *, Zhu, C., Zhang, Y., Chen, H., Qin, W., Wang, M., Li, K., A longitudinal diffusion tensor imaging study on Wallerian degeneration of corticospinal tract after motor pathway stroke, Neuroimage, 2009, 47(2): 451-458.

      (44)Song, M., Zhou, Y., Li, J., Liu, Y., Tian, L., Yu, C. *, Jiang T. *, Brain spontaneous functional connectivity and intelligence, Neuroimage, 2008, 41(3): 1168-1176.



    • 获奖与荣誉称号

      2014年,医学影像学专业多层次人才培养模式的系统规划与实践,天津市级教学成果奖二等奖

      2014年,MR应用技术创新在隐匿性脑损伤机制研究和脑重大疾病诊疗中的应用,教育部科学技术进步一等奖

      2013年,缺血性脑梗死的功能影像学研究,天津市科学技术进步奖一等奖

      2013年,脑重大疾病磁共振评价体系及诊疗关键技术与临床应用,中华医学科技奖二等奖