脑影像公共数据库
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  • 脑影像公共数据库

    Cohort Analysis Study Design Ancestry Total N N Females Mean Age (SD) Age Range SCZ database sample size mode charge acquisition onset/first-episode  others
    AddNeuroMed Discovery Case-control (AD, MCI and health controls) European 357 204 74.4 (6.4) 53 - 90 MCIC 378188 patients+190 controls    final331162 patients+169 controls sMRI fMRI(4tasks)           DWI free http://coins.mrn.org/ nearly 1/3 4 sites  cooperation with BIRN
    ADNI Discovery Case-Control (AD, MCI, healthy control) European 747 302 75.4 (6.9) 55 - 91 •200 Normal Controls
    •400 MCI
    •200 Mild AD

    MRI\PIB\FDG\Biosamples Free http://adni.loni.usc.edu  400 subjects diagnosed with MCI, 200 subjects with early AD and 200 elderly control subjects.

    also apply for AIBL data,
     DOD ADNI data
    ADNI2GO Discovery Case-Control (AD, MCI, healthy control) European 362 203 72.8 (7.4) 55 - 91 GO:•200 EMCI (new)
    •500 Normal Controls and MCI from ADNI1 2
    •150 Normal Controls (new)
    •450-500 CN and MCI from ADNI1 (approximate)
    •150 EMCI (new)
    •200 EMCI from ADNI GO (approximate)
    •150 LMCI (new)
    •200 mild AD (new)

    MRI\FDG\Biosamples
    \FMRI\DTI\AV45
    Free http://adni.loni.usc.edu Goexisting ADNI1 cohort and added 200 participants identified as EMCI                        2 ADNI1/ADNI GO cohort in addition to 150 elderly controls, 100 EMCI 150 LMCI 150 mild AD patients.

    Betula Discovery Population-based European 353 185 62.3 (13.3) 25 - 95 3,000 subjects whose ages were 35, 40, 45, 50, 55, 60, 65, 70, 75, and 80 years when first tested http://www.betula.su.se/en 1000 randomly
     selected individs 
    the relationships between subjective
     (i.e., self-rating) and objective (blood and urine parameters, blood pressure and pulse, medication, recent contacts with a physician, and sensory function) indexes of health,
    BFS Discovery Population-based European 220 115 24 (7.9) 15 - 60  51 controls and 81 high-risk (HR) individuals FMRI GWAS http://www.ed.ac.uk/psychiatry/research/bipolar-family-study  Bipolar Family Study 
    BIG Discovery Population-based European 1300 747 22.9 (3.8) 18 - 41 2500 participants
    Study population: healthy population, aged 45 and older
     1.5T or a 3.0T Siemens MRI       DTI        VBM http://www.cognomics.nl/big.html Investigating the role of known risk factors for psychiatric disease in more than 1,000 individuals
    BrainSCALE Discovery Population-based Twin Study European 277 147 10.0 (1.3) 9 - 15 112 families, with
    9-year-old twins and an older sibling. Three years later, 89 families returned for follow-up assessment.
     
    190 + 125 twins MRI http://brainscales.kip.uni-heidelberg.de/index.html 190
    BRCDECC Discovery Case-control (MDD and healthy controls) European 169 105 49.9 (8.6) 26 - 71
    EPIGEN Discovery Epilepsy cases European 233 138 38.5 (12.7) 14 - 85  1,606 baseline
     cohort participants  final:1341(>60 year old)
    http://www.epigen.it/categories/project 370529SNPs
    GIG Discovery Population-based European 299 179 24.2 (2.4) 19 - 31 224 young
     (aged 18–31 years)
    fMRI  maging and performance
    data for at least 70% of alltrials, and MAD1L1 rs11764590 genotype were availablefor 224 participants (exclusion criteria were unavailabilityof genotype in 12 cases, failure of fMRI data acquisitionin 7 cases, and fMRI motion artifacts and/or less than 70%correct answers across all task conditions in 56 cases)
    GSP Discovery Population-based European 442 251 21.4 (3.2) 18 - 35 1,570 participants ages 18 to 35 years  T1-weighted structural MRI scan and either one (n=1,570) or two (n=1,139) resting state functional MRI scans http://neuroinformatics.harvard.edu/gsp/ For the majority of participants
     self-report behavioral and cognitive measures are included (n=926 and n=892 respectively). Analyses of data quality, structure, function, personality, and cognition are presented to demonstrate the dataset’s utility.
     HUBIN Discovery Case-control (SCZ and healthy controls) European 200 70 41.8 (8.1) 19 - 56 Human Brain Informatics Center
    IMAGEN Discovery Population-based European 1765 895 14.6 (0.4) 13 - 17  2000 +14 year old adolescents FMRI GWAS https://imagen-europe.com/ 1326
    MCIC  # Discovery Case-control (SCZ and healthy controls) European 170? 58 34.0 (11.2) 18 - 60
    MooDS Discovery Population-based European 311 164 33.4 (9.8) 18 - 51 7,481 patients and 9,250 controls
    from the aforementioned PGC-BD study (MooDS-PGC).
    MPIP Discovery Case-control (MDD and healthy controls) European 550 318 48.3 (13.3) 18 - 87 866 patients in the MPIP
    data base who had sustained a first AMI.
     AMI by region and
    severity. The 4 regions are anterior, lateral, inferior and posterior
    https://www.melanoma.org/find-support/patient-community/mpip-melanoma-patients-information-page/search
    NCNG Discovery Population-based European 327 223 51.8 (16.7) 19 - 79 670 persons
     in the Oslo and Bergen urban areas
     T1 MP-RAGE ; DTI FA ; DTI FA Col; DTI MD; rFMRIT2 FLAIR  APOE, CHRNA4 http://www.sv.uio.no/psi/english/research/projects/neurogenetics_aging/
    NESDA Discovery Case-control (Depression, Anxiety, and healthy controls) European 231 153 37.8 (10.1) 18 - 57  2981 participants
    aged 18 through 65 years
    Genetic measures FMRI http://www.nesda.nl/nieuws/
    neuroIMAGE Discovery ADHD cases European 154 23 17.0 (2.5) 11 - 24 506 participants with
    an ADHD diagnosis, 350 unaffected siblings, and 283 healthy controls
    Four measures: working
    memory, verbal fluency, response inhibition and cognitive
    flexibility
    http://www.neuroimage.nl/index.php?option=com_content&view=article&id=92&Itemid=99

    21% NeuroIMAGE study
    comprehends an assessment
    of 1,069 children
     (751 from ADHD families;
    318 from CON families) and 848 parents (582 from ADHD families; 266 from CON families).
    NTR - Adults Discovery Population-based Twin Study European 400 238 29.7 (10.7) 12 - 56 112 families, with
    9-year-old twins and an older sibling. Three years later, 89 families returned for follow-up assessment. 
    1.5 T MRI http://www.tweelingenregister.org/ Data collection included psychometric IQ tests, a comprehensive neuropsychological testing protocol,
    and parental and self-ratings of behavioral and emotional problems.
    OATS Discovery Population-based Twin study European 364 238 70.5 (5.1) 65 - 89 Participants included 117 pairs of
    monozygotic twins, 98 pairs of dizygotic twins, and 42
    single twins, with a mean age of 71.
    four measures: working
    memory, verbal fluency, response inhibition and cognitive
    flexibility
    https://cheba.unsw.edu.au/project/older-australian-twins-study 472 OATS participants,
    comprising 117 pairs of MZ twins, 98 pairs of DZ
    twins, and 42 individuals 
    PAFIP  Discovery Case-control (SCZ and healthy controls) European 117 45 28.4 (8.1) 16 - 51 ongoing
    QTIM Discovery Population-based Twin Study European 845 527 22.5 (3.2) 16 - 30 639 subjects structural MRI scans single 4 Tesla    T1  genome-wide genotyping data\Diffusion weighted
    images (DWI)
    http://www.qimrberghofer.edu.au/qtwin/ 672 subjects before 2011                 639 subjects from 364 families (98 monozygotic twin pairs; 127 dizygotic twin pairs; 3 dizygotic triplet trios; 117 singletons; 63 siblings; 23.1±3.1 years; 251 men and 388 women).

               
    The Queensland Twin Imaging Study (QTIM) is an ongoing, 5-year longitudinal project tasked with identifying genetic influences on brain structure. 
    SHIP Discovery Population-based European 966 507 56.4 (12.6) 31 - 90 Approximately 4000
     volunteers 
    WB-MRI 
     Two hundred healthy volunteers (99 women, 101 men; mean age 48.3 years) underwent a standardized WB-MRI protocol. The protocol was supplemented by contrast-enhanced cardiac MRI and magnetic resonance (MR) angiography in 61 men (60.4%) and cardiac MRI and MR mammography in 44 women (44.4%). 
    http://www2.medizin.uni-greifswald.de/cm/fv/ship/datennutzung/
    SHIP-TREND Discovery Population-based European 858 477 50.0 (13.5) 21 - 81 4420 participants
     (49.4% men; age 20–82 years).
     normal glucose
     tolerance (NGT), prediabetes, newly detected type 2 diabetes (T2DM), known T2DM with HbA1c<7.0%, known T2DM with HbA1c
    7.0%.
    http://www.medizin.uni-greifswald.de/cm/fv/ship/datennutzung/
    Sydney MAS Discovery Population-based European 543 297 78.4 (4.7) 70 - 90 (N = 1037) aged 70-90  Structural MRI scans
    were performed on 554 individuals
      subgroups participated functional MRI
    https://cheba.unsw.edu.au/project/sydney-memory-and-ageing-study underwent detailed neuropsychiatric and medical
    assessments and donated a blood sample for clinical chemistry, proteomics and genomics. and subgroups participated in studies of falls and balance, metabolic and inflammatory markers
    TOP Discovery Case-control (SCZ, BD, other psychoses, and healthy controls) European 849 407 34.0 (10.4) 17 - 73
    UMCU Discovery Case-control (SCZ and healthy controls) European 279 73 31.9 (11.7) 17 - 68 the University Medical Centre Utrecht