Cohort | Analysis | Study Design | Ancestry | Total N | N Females | Mean Age (SD) | Age Range | SCZ | database | sample size | mode | charge | acquisition | onset/first-episode | others | |
AddNeuroMed | Discovery | Case-control (AD, MCI and health controls) | European | 357 | 204 | 74.4 (6.4) | 53 - 90 | MCIC | 378(188 patients+190 controls) final:331(162 patients+169 controls) | sMRI fMRI(4tasks) DWI | free | http://coins.mrn.org/ | nearly 1/3 | 4 sites | cooperation with BIRN | |
ADNI | Discovery | Case-Control (AD, MCI, healthy control) | European | 747 | 302 | 75.4 (6.9) | 55 - 91 |
•200 Normal
Controls •400 MCI •200 Mild AD |
MRI\PIB\FDG\Biosamples | Free | http://adni.loni.usc.edu |
400 subjects diagnosed with MCI, 200
subjects with early AD and 200 elderly control subjects. |
also apply for AIBL data, DOD ADNI data |
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ADNI2GO | Discovery | Case-Control (AD, MCI, healthy control) | European | 362 | 203 | 72.8 (7.4) | 55 - 91 |
GO:•200 EMCI
(new) •500 Normal Controls and MCI from ADNI1 2:•150 Normal Controls (new) •450-500 CN and MCI from ADNI1 (approximate) •150 EMCI (new) •200 EMCI from ADNI GO (approximate) •150 LMCI (new) •200 mild AD (new) |
MRI\FDG\Biosamples \FMRI\DTI\AV45 |
Free | http://adni.loni.usc.edu |
Go:existing ADNI1 cohort and added 200
participants identified as EMCI 2: ADNI1/ADNI GO cohort in addition
to 150 elderly controls, 100 EMCI, 150 LMCI 150 mild AD patients. |
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Betula | Discovery | Population-based | European | 353 | 185 | 62.3 (13.3) | 25 - 95 | 3,000 subjects whose ages were 35, 40, 45, 50, 55, 60, 65, 70, 75, and 80 years when first tested | http://www.betula.su.se/en |
1000 randomly selected individs |
the relationships between
subjective (i.e., self-rating) and objective (blood and urine parameters, blood pressure and pulse, medication, recent contacts with a physician, and sensory function) indexes of health, |
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BFS | Discovery | Population-based | European | 220 | 115 | 24 (7.9) | 15 - 60 | 51 controls and 81 high-risk (HR) individuals | FMRI GWAS | http://www.ed.ac.uk/psychiatry/research/bipolar-family-study | Bipolar Family Study | |||||
BIG | Discovery | Population-based | European | 1300 | 747 | 22.9 (3.8) | 18 - 41 |
2500 participants Study population: healthy population, aged 45 and older |
1.5T or a 3.0T Siemens MRI DTI VBM | http://www.cognomics.nl/big.html | Investigating the role of known risk factors for psychiatric disease in more than 1,000 individuals | |||||
BrainSCALE | Discovery | Population-based Twin Study | European | 277 | 147 | 10.0 (1.3) | 9 - 15 |
112
families, with 9-year-old twins and an older sibling. Three years later, 89 families returned for follow-up assessment. |
190 + 125 twins MRI | http://brainscales.kip.uni-heidelberg.de/index.html | 190 | |||||
BRCDECC | Discovery | Case-control (MDD and healthy controls) | European | 169 | 105 | 49.9 (8.6) | 26 - 71 | |||||||||
EPIGEN | Discovery | Epilepsy cases | European | 233 | 138 | 38.5 (12.7) | 14 - 85 |
1,606 baseline cohort participants final:1341(>60 year old) |
http://www.epigen.it/categories/project | 370529SNPs | ||||||
GIG | Discovery | Population-based | European | 299 | 179 | 24.2 (2.4) | 19 - 31 |
224 young (aged 18–31 years) |
fMRI |
maging and performance data for at least 70% of alltrials, and MAD1L1 rs11764590 genotype were availablefor 224 participants (exclusion criteria were unavailabilityof genotype in 12 cases, failure of fMRI data acquisitionin 7 cases, and fMRI motion artifacts and/or less than 70%correct answers across all task conditions in 56 cases) |
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GSP | Discovery | Population-based | European | 442 | 251 | 21.4 (3.2) | 18 - 35 | 1,570 participants ages 18 to 35 years | T1-weighted structural MRI scan and either one (n=1,570) or two (n=1,139) resting state functional MRI scans | http://neuroinformatics.harvard.edu/gsp/ |
For the majority of
participants self-report behavioral and cognitive measures are included (n=926 and n=892 respectively). Analyses of data quality, structure, function, personality, and cognition are presented to demonstrate the dataset’s utility. |
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HUBIN | Discovery | Case-control (SCZ and healthy controls) | European | 200 | 70 | 41.8 (8.1) | 19 - 56 | Human Brain Informatics Center | ||||||||
IMAGEN | Discovery | Population-based | European | 1765 | 895 | 14.6 (0.4) | 13 - 17 | 2000 +14 year old adolescents | FMRI GWAS | https://imagen-europe.com/ | 1326 | |||||
MCIC # | Discovery | Case-control (SCZ and healthy controls) | European | 170? | 58 | 34.0 (11.2) | 18 - 60 | |||||||||
MooDS | Discovery | Population-based | European | 311 | 164 | 33.4 (9.8) | 18 - 51 |
7,481 patients and 9,250
controls from the aforementioned PGC-BD study (MooDS-PGC). |
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MPIP | Discovery | Case-control (MDD and healthy controls) | European | 550 | 318 | 48.3 (13.3) | 18 - 87 |
866 patients in the MPIP data base who had sustained a first AMI. |
AMI by region and severity. The 4 regions are anterior, lateral, inferior and posterior |
https://www.melanoma.org/find-support/patient-community/mpip-melanoma-patients-information-page/search | ||||||
NCNG | Discovery | Population-based | European | 327 | 223 | 51.8 (16.7) | 19 - 79 |
670 persons in the Oslo and Bergen urban areas |
T1 MP-RAGE ; DTI FA ; DTI FA Col; DTI MD; rFMRIT2 FLAIR APOE, CHRNA4 | http://www.sv.uio.no/psi/english/research/projects/neurogenetics_aging/ | ||||||
NESDA | Discovery | Case-control (Depression, Anxiety, and healthy controls) | European | 231 | 153 | 37.8 (10.1) | 18 - 57 |
2981 participants aged 18 through 65 years |
Genetic measures FMRI | http://www.nesda.nl/nieuws/ | ||||||
neuroIMAGE | Discovery | ADHD cases | European | 154 | 23 | 17.0 (2.5) | 11 - 24 |
506 participants with an ADHD diagnosis, 350 unaffected siblings, and 283 healthy controls |
Four measures: working memory, verbal fluency, response inhibition and cognitive flexibility |
http://www.neuroimage.nl/index.php?option=com_content&view=article&id=92&Itemid=99 |
21% |
NeuroIMAGE study comprehends an assessment of 1,069 children (751 from ADHD families; 318 from CON families) and 848 parents (582 from ADHD families; 266 from CON families). |
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NTR - Adults | Discovery | Population-based Twin Study | European | 400 | 238 | 29.7 (10.7) | 12 - 56 |
112 families, with 9-year-old twins and an older sibling. Three years later, 89 families returned for follow-up assessment. |
1.5 T MRI | http://www.tweelingenregister.org/ |
Data collection included
psychometric IQ tests, a comprehensive neuropsychological testing
protocol, and parental and self-ratings of behavioral and emotional problems. |
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OATS | Discovery | Population-based Twin study | European | 364 | 238 | 70.5 (5.1) | 65 - 89 |
Participants included 117 pairs
of monozygotic twins, 98 pairs of dizygotic twins, and 42 single twins, with a mean age of 71. |
four measures: working memory, verbal fluency, response inhibition and cognitive flexibility |
https://cheba.unsw.edu.au/project/older-australian-twins-study |
472 OATS participants, comprising 117 pairs of MZ twins, 98 pairs of DZ twins, and 42 individuals |
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PAFIP | Discovery | Case-control (SCZ and healthy controls) | European | 117 | 45 | 28.4 (8.1) | 16 - 51 | ongoing | ||||||||
QTIM | Discovery | Population-based Twin Study | European | 845 | 527 | 22.5 (3.2) | 16 - 30 | 639 subjects |
structural
MRI scans single 4
Tesla T1 genome-wide genotyping data\Diffusion
weighted images (DWI) |
http://www.qimrberghofer.edu.au/qtwin/ |
672 subjects before 2011 639 subjects from 364
families (98 monozygotic twin pairs; 127 dizygotic twin pairs; 3 dizygotic
triplet trios; 117 singletons; 63 siblings; 23.1±3.1 years; 251 men and 388
women). |
The Queensland Twin Imaging Study (QTIM) is an ongoing, 5-year longitudinal project tasked with identifying genetic influences on brain structure. | ||||
SHIP | Discovery | Population-based | European | 966 | 507 | 56.4 (12.6) | 31 - 90 |
Approximately 4000 volunteers |
WB-MRI Two hundred healthy volunteers (99 women, 101 men; mean age 48.3 years) underwent a standardized WB-MRI protocol. The protocol was supplemented by contrast-enhanced cardiac MRI and magnetic resonance (MR) angiography in 61 men (60.4%) and cardiac MRI and MR mammography in 44 women (44.4%). |
http://www2.medizin.uni-greifswald.de/cm/fv/ship/datennutzung/ | ||||||
SHIP-TREND | Discovery | Population-based | European | 858 | 477 | 50.0 (13.5) | 21 - 81 |
4420 participants (49.4% men; age 20–82 years). |
normal glucose tolerance (NGT), prediabetes, newly detected type 2 diabetes (T2DM), known T2DM with HbA1c<7.0%, known T2DM with HbA1c≥7.0%. |
http://www.medizin.uni-greifswald.de/cm/fv/ship/datennutzung/ | ||||||
Sydney MAS | Discovery | Population-based | European | 543 | 297 | 78.4 (4.7) | 70 - 90 | (N = 1037) aged 70-90 |
Structural MRI
scans were performed on 554 individuals , subgroups participated functional MRI |
https://cheba.unsw.edu.au/project/sydney-memory-and-ageing-study |
underwent detailed
neuropsychiatric and medical assessments and donated a blood sample for clinical chemistry, proteomics and genomics. and subgroups participated in studies of falls and balance, metabolic and inflammatory markers |
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TOP | Discovery | Case-control (SCZ, BD, other psychoses, and healthy controls) | European | 849 | 407 | 34.0 (10.4) | 17 - 73 | |||||||||
UMCU | Discovery | Case-control (SCZ and healthy controls) | European | 279 | 73 | 31.9 (11.7) | 17 - 68 | the University Medical Centre Utrecht |